Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-126-9 | CAS number: 1746-23-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- A study was conducted to determine the toxicity of the test substance to Sprague-Dawley rats exposed by inhalation for 6 h. A group of 5 male and 5 female rats were exposed (whole body) to the test substance at a nominal concentration of 3500 ppm (i.e. 16891.62 mg/m3, or 17.8 mg/L) and were then observed for 14 d.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Vinyltoluene
- EC Number:
- 246-562-2
- EC Name:
- Vinyltoluene
- Cas Number:
- 25013-15-4
- Molecular formula:
- C9H10
- IUPAC Name:
- Ethenylmethylbenzene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Charles River, Wilmington, USA
- Weight at study initiation: Males, 241-258 g; Females, 210-230 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- A single 4 h inhalation exposure was performed.
The test substance vapour was generated using a heated-flask flash evaporator. A fluid metering pump was used to draw the test substance from a 250 mL flask containing approximately 75 mL of test substance. The test substance was pumped through a coil of 1/8” teflon tubing which was immersed in a water bath (50-85°C). The heated test substance was then delivered to the flash evaporator through teflon tubing. Dry air, at a flow rate of 15 L/minute, was passed through a coil of 1/4 copper tubing which was immersed in a water bath (90-96°C). The dry air was heated to 30°C through the coil and was delivered to the flash evaporator. The test substance was vaporised by allowing the heated dry air to pass over the tip of the teflon tubing containing the heated test substance. The vaporisation occurred in a 1 L Erlenmeyer flask heated to approximately 65°C using a heating mantle. The test atmosphere was directed, undiluted, into a 26.5 L glass exposure chamber housing the animals. Chamber temperature range was 25-28°C during the 4 h exposure.
The generation flask, connecting tubing, stopper, and clamp were weighed before and after the exposure. The difference in weight represented the total amount of test substance delivered into the chamber; this, divided by the total volume of air delivered yielded the nominal exposure concentration.
Nominal test material concentration:
During the exposure, a total of 61.85 g of test substance was delivered in a total volume of 3,600 L of air, yielding a nominal exposure concentration of 17.18 mg/L, equivalent to approximately 3500 ppm (mol.wt. 118; 1 mg/L = 207 ppm). - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 3500 ppm (nominal)
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing:
Clinical signs: 15 min intervals during the first hour of exposure, then hourly for the remainder of the exposure; on removal of the animals from the chamber; hourly for 4 h post-exposure; and daily thereafter for 14 d.
Body weights: Day 0 (prior to exposure) and on Days 1, 2, 4, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: on Day 14, all animals were killed by exsanguination under ethyl ether anaesthesia and a macroscopic examination was performed at necropsy.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 16 891 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: During exposure, all animals showed respiratory abnormalities and increased ocular, nasal, and oral secretions, commencing after 15 minutes. After removal from the chamber, neuromuscular abnormalities were also noted, including weakness, loss of reflex ac
- Body weight:
- Small transient weight losses were noted in all animals; body weights recovered by day 7 for most animals.
- Gross pathology:
- There were no remarkable macroscopic findings at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the study conditions, ocular, nasal and oral irritation was noted during exposure, decreasing 4 h post-exposure. Neuromuscular impairment was noted after exposure, increasing in severity 4 h post-exposure. All clinical signs had abated by Day 3. Small transient weight losses were noted for all animals. Macroscopic findings at necropsy were unremarkable. The 4 h LC50 was therefore >3500 ppm (i.e. 16891.62 mg/m3, or 17.8 mg/L).
- Executive summary:
A study was conducted to determine the toxicity of the test substance to Sprague-Dawley rats exposed by inhalation for 6 h. A group of 5 male and 5 female rats were exposed (whole body) to the test substance at a nominal concentration of 3500 ppm (i.e. 16891.62 mg/m3, or 17.8 mg/L) and were then observed for 14 d. Mortality and clinical signs were recorded frequently during and immediately after exposure and daily thereafter. Body weights were determined on Day 0 (prior to exposure) and on Days 1, 2, 4, 7 and 14. At necropsy, a macroscopic examination was performed on all animals. Under the study conditions, ocular, nasal and oral irritation was noted during exposure, decreasing 4 h post-exposure. Neuromuscular impairment was noted after exposure, increasing in severity 4 h post-exposure. All clinical signs had abated by Day 3. Small transient weight losses were noted for all animals. Macroscopic findings at necropsy were unremarkable. The 4 h LC50 was therefore >3500 ppm (i.e. 16891.62 mg/m3 or 17.8 mg/L) (Norvell, 1980).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.