Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to OCED/EU guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
682
Temp.:
23 °C
pH:
2
Type:
log Pow
Partition coefficient:
2.8
Temp.:
23 °C
pH:
2
Type:
Pow
Partition coefficient:
20.3
Temp.:
23 °C
pH:
5.7
Type:
log Pow
Partition coefficient:
1.3
Temp.:
23 °C
pH:
5.7
Type:
Pow
Partition coefficient:
0.53
Temp.:
23 °C
pH:
7
Type:
log Pow
Partition coefficient:
-0.3
Temp.:
23 °C
pH:
7

Any other information on results incl. tables

The partition coefficients 1-octanol /water of the test item in distilled water, at pH 2 and at pH 7 at room temperature (23°C) were

determined according to the "shake flask method" described in EEC Test Guideline 92/69, A.8., OECD Test Guideline 107 and EPA Product Properties Test Guideline OPPTS 830.7550.

The concentrations of the test item in the 1 -octanol phases and in the aqueous phases were quantified by HPLC analyses.

The used HPLC method (reversed phase) was validated and found to be valid.

Applicant's summary and conclusion