Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The structurally similar material, undecenyl methoxycrylene (UMC), was tested in vitro in the Episkin Reconstituted Human Epidermis Model for skin irritation.  The eye irritation potential of the surrogate material UMC was tested for eye irritation potential in vitro in the SkinEthic Reconstituted Corneal Model.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin Irritation:

The structurally similar material, UMC, was rated "not irritating" when tested in vitro in the Episkin Reconstituted Human Epidermis Test. These results suggest that there is very little potential for the test material to be an irritant and would not be classified as dangerous according to either the DSD or GHS.

Eye Irritation:

The structurally similar material, UMC, also produced a negative response for eye irritation, when tested in the SkinEthic Reconstituted Corneal Model using human corneal epithelial tissue. These results suggest that the test material has little or no potential for eye irritation.


Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

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