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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001 - 2002
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide
EC Number:
616-054-9
Cas Number:
74149-74-9
Molecular formula:
C19 H20 N4 O3
IUPAC Name:
N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
white solid substance

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
not specified
Controls:
yes, concurrent no treatment
Duration of treatment / exposure:
4 hours
Observation period:
72 hours sfter dosing
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 72 hours
Score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
no irritant effects observed
Executive summary:

Considering the reported data of this irritation study it can be stated that the test item Aminopyriazinon showed no irritant/corrosive effects.

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