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EC number: 215-304-0 | CAS number: 1320-51-0
The acute oral toxicity of the test substance EXP 3982 N-2-hydroxyethylurea containing 57.58% of the active ingredient hydroxyethyl urea was studied under GLP in a study according to OECD TG 401. After a preliminary study with doses ranging from 868 to 3473 mg/kg (corresponding to 500 to 2000 mg/kg active ingredient), a final limit test was conducted with a single dose of 3473 mg/kg corresponding to 2000 mg/kg active ingredient. Five male rats (10 to 11 weeks old, weighing 298 to 335 g) and five female rats (10 weeks old, weighing 187 to 226 g) of the Sprague-Dawley strain were fasted overnight and received a single oral dose of the test material by gavage at a volume of 3.05 mL/kg. Animals were housed individually in suspended cages and observed for a period of 14 days. Animals received food and drinking water ad libitum. At the end of the observation period the animals were sacrificed and a gross necropsy was performed on all animals. No mortality occurred after dosing or during the 14-day observational period. No significant clinical observations and findings at necropsy were made. Bodyweight development was normal. The LD50 value was greater than 3473 mg/kg for the formulation, which corresponds to >2000 mg/kg for the active ingredient.
Based of the lack of any significant toxicity at 2000mg/kg, hydroxyethyl urea is not classified for acute dermal toxicity according to GHS.
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