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EC number: 204-847-9 | CAS number: 127-52-6
Table 1 Excretion of HO36Cl in ratsa
Collection period (h)
Proportion of HO36Cl excreted (%)
aValues represent mean±SE from four treated (fasted) rats, expressed as the proportion of administration dose. 36Cl was not detected in expired air throughout the 96 h studied.
Table 2 The distribution of 36Cl activity 96 h after administration of HO36Cl orally
36Cl activity (µg/g)
Toxicokinetics of Chloramine-T after single 30 mg/kg i.v. and 100 mg/kg p.o. were studied in male Wistar Rats. Serial blood samples were collected and plasma concentrations of Chloramine-T were determined by HPLC method. Chloramine-T was characterized by a rapid distribution and elimination phase (distribution half-life 0.12 hr – i.v. and 0.42 hr. – p.o.; elimination half-life 1.41 hr – i.v. and 1.98 hr – p.o.). Plasma clearance was relatively high (0.147 L/hr – i.v., 0.149 L/hr – p.o.) with a volume of distribution at steady state of 0.24 L. Chloramine-T was found to be rapidly distributed and eliminated. After 96 h, 36% was eliminated via the urine, whereas 15% was eliminated via faeces.
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