Registration Dossier
Registration Dossier
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EC number: 700-340-6 | CAS number: 76524-94-2
Endpoint summary
Administrative data
Description of key information
In vitro skin irritation study with human tissue: Not irritating
In vitro eye irritation (BCOP): Not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
An in vitro skin irritation test was performed according to OECD guideline 439 (In vitroSkin Irritation: Reconstructed Human Epidermis Test Method). Tissue samples were treated in triplicates with Y-15864, deionised water (negative control) and 5% sodium lauryl sulfate (positive control) for 15 minutes. Test items were washed off and after further 42 hours incubation the viability of the cells was determined by the OD570 in a MTT-Assay. After treatment with the test item Y-15864 the relative absorbance values decreased to 88.9%. This value is above the threshold for irritancy of ≤ 50%. Therefore, the test item is not considered to possess an irritant potential.
Eye irritation:
The eye irritancy potential of Y-15864 was investigated in the bovine corneal opacity and permeability assay according to OECD guideline 437. The test item was tested undiluted. A mean in vitro irritation score of 18.51 was calculated. Relative to the negative (mean in vitro irritation score = 0.99) and positive (mean irritation score = 71.07) control, the test item did not cause a relevant increase of the corneal opacity or permeability.
According to OECD 437 the test item is classified as not corrosive / not severe irritant to the eye.
Justification for classification or non-classification
According to DSD (67/548/EEC) and CLP (1272/2008/EC) Y-15864 does not meet the criteria to be classified regarding this endpoint.
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