Registration Dossier
Registration Dossier
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EC number: 204-552-5 | CAS number: 122-52-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- publication
- Title:
- Acute evaluation of triethyl phosphite.
- Author:
- Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
- Year:
- 1 992
- Bibliographic source:
- Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Materials and methods
- Principles of method if other than guideline:
- Ten Fischer 344 rats per sex and dose were treated with 1000, 1500, 2000, 2500, 3000 and 4000 mg/kg bw by gavage. Clinical signs were observed and LD50 was determined.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethylphosphite
- IUPAC Name:
- Triethylphosphite
- Details on test material:
- Purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were fasted prior to dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Mazola corn oil
- Details on oral exposure:
- The test substance was mixed with Mazola corn oil and administered at constant volumes of 1% body weight.
- Doses:
- 1000, 1500, 2000, 2500, 3000 and 4000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Details on study design:
- Check for mortality and observations was performed throughout the 14 day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 470 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 220 - 2 730
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 840 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 630 - 2 140
- Mortality:
- Mortality occured. Most deaths occured within 24 hours after dosing. no further details.
- Clinical signs:
- Rapid breathing and tremors were observed prior to death.
- Body weight:
- Survivors gained weight during observation period.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
