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Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V B7
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals

Species:
other: Wistar rat, KFM Han, outbred SPF-quality

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
Diet
Duration of treatment / exposure:
28 days
No. of animals per sex per dose:
Male: 5 animals at 0mg/kg bw/day
Male: 5 animals at 33mg/kg bw/day
Male: 5 animals at 134mg/kg bw/day
Male: 5 animals at 750mg/kg bw/day
Female: 5 animals at 0mg/kg bw/day
Female: 5 animals at 35mg/kg bw/day
Female: 5 animals at 140mg/kg bw/day
Female: 5 animals at 760mg/kg bw/day

Results and discussion

Results of examinations

Details on results:
Clinical observations: No death occur.
Body weight gains were reduced for both sexes of group 4 (15% males and approximately 5% for females relative to respective controls)
Lab findings: Haematology: the changes observed were not considered to be significant in toxicological terms.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Not classified

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