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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V B7
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals

Species:
other: Wistar rat, KFM Han, outbred SPF-quality

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
Diet
Duration of treatment / exposure:
28 days
No. of animals per sex per dose:
Male: 5 animals at 0mg/kg bw/day
Male: 5 animals at 33mg/kg bw/day
Male: 5 animals at 134mg/kg bw/day
Male: 5 animals at 750mg/kg bw/day
Female: 5 animals at 0mg/kg bw/day
Female: 5 animals at 35mg/kg bw/day
Female: 5 animals at 140mg/kg bw/day
Female: 5 animals at 760mg/kg bw/day

Results and discussion

Results of examinations

Details on results:
Clinical observations: No death occur.
Body weight gains were reduced for both sexes of group 4 (15% males and approximately 5% for females relative to respective controls)
Lab findings: Haematology: the changes observed were not considered to be significant in toxicological terms.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Not classified