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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V B5
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand Rabbits, KFM (SPF quality)

Test system

Amount / concentration applied:
100mg
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Time point:
other: 1h
Score:
0.3
Irritation parameter:
overall irritation score
Time point:
other: 24, 48 and 72h
Score:
0
Other effects:
At one hour, a score of one was seen in one animal. No inflammation was observed between 24 and 72 hours.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU

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