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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guideline 402 Annex V B3
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Test animals

Species:
other: Rat, KFM-Han, wistar (outbred, SPF quality)

Administration / exposure

Vehicle:
other: Distilled water containing 4% carboxymethylcellulose sodium salt

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000mg/kg bw; number of animals: 5; number of deaths:0
Female: 2000mg/kg bw; number of animals: 5; number of deaths:0
Gross pathology:
Effects on organs: No macroscopic organ changes were observed.
Other findings:
Signs of toxicity (local): All the male rats showed a slight erythema at day 2, but recovered within 5 days.
All the females rats showed a slight erythema at day 3 until terminatioon of observation.

Applicant's summary and conclusion

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