Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guidelines for testing of Chenicals, Guideline No.417; "Toxicokinetics" adopted April 4, 1984
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
EC Number:
401-990-0
EC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Cas Number:
106990-43-6
Molecular formula:
C132H250N32
IUPAC Name:
N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
Radiolabelling:
yes

Test animals

Species:
other:

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: com oil
Details on exposure:
a single dose via oral gavage
No. of animals per sex per dose / concentration:
Male: 4 animals at CA 50mg/kg
Male: 4 animals at CA 1000mg/kg
Details on dosing and sampling:
The purpos of this study is to obtain information on the absorption, distribution and excretion (ADE) of 14C-chimassorb 119 as a function of oral dosage level. This information may be used as an aid in the evaluation and interpretation of other toxicology studies and the study results amy contribute to provide a rational basis of toxicological ris assessment in man.

Results and discussion

Any other information on results incl. tables

After oral dose of 50 and 1000mg of 14C-chimassorb 119 per kg body weight, the excretion of total radioactivity in virtually complete within 96 hours after administration. Radioactivity is excreted nearly entirely via faeces (96 -99% of recovered radio label). Renal excretion is very low (0.28 -0.60% of the dose), and excretion of radio activity via expired arie negligible (<=0.01% of the dose). There is hardly any retention of radio activity in tissues. There was no significant bioconcentration or accumulation in any of the organs in vestigated.

Applicant's summary and conclusion

Categories Display