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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EPISKIN-SM reconstituted human epidermis
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
N6-(1-oxooctyl)-L-lysine
EC Number:
245-854-7
EC Name:
N6-(1-oxooctyl)-L-lysine
Cas Number:
23735-96-8
Molecular formula:
CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
IUPAC Name:
(2S)-2-amino-6-octanamidohexanoic acid

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: other: in vitro assay; cell viability (MTT assay)
Value:
0.508
Remarks on result:
other:
Remarks:
Time point: 4 hrs. Remarks: Viability: 79% - Neg. control: 0.641 or 100%; Pos. control: 0.015 or 2.4%. (migrated information)

In vivo

Irritant / corrosive response data:
The test item is not corrosive.

Applicant's summary and conclusion

Conclusions:
Amihope OL was not a skin corrosive in the EPISKIN model test.

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