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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EPISKIN-SM reconstituted human epidermis
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
N6-(1-oxooctyl)-L-lysine
EC Number:
245-854-7
EC Name:
N6-(1-oxooctyl)-L-lysine
Cas Number:
23735-96-8
Molecular formula:
CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
IUPAC Name:
(2S)-2-amino-6-octanamidohexanoic acid

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: other: in vitro assay; cell viability (MTT assay)
Value:
0.508
Remarks on result:
other:
Remarks:
Time point: 4 hrs. Remarks: Viability: 79% - Neg. control: 0.641 or 100%; Pos. control: 0.015 or 2.4%. (migrated information)

In vivo

Irritant / corrosive response data:
The test item is not corrosive.

Applicant's summary and conclusion

Conclusions:
Amihope OL was not a skin corrosive in the EPISKIN model test.