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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
other:
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N6-(1-oxooctyl)-L-lysine
EC Number:
245-854-7
EC Name:
N6-(1-oxooctyl)-L-lysine
Cas Number:
23735-96-8
Molecular formula:
CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
IUPAC Name:
(2S)-2-amino-6-octanamidohexanoic acid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
Test animals: Crl:WI (Charles River Deutschland)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg
No. of animals per sex per dose:
2 x 3 rats
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
none
Clinical signs:
other: On the day of application, after 0.5, 2 and 4 hrs piloerection was observed in all 6 rats. Additionally, all 6 rats showed a hunched posture after 2 hrs. After 6 hrs and from day 1 to day 14, all rats were free of any abnormalities.
Gross pathology:
No pathological signs observed

Applicant's summary and conclusion

Conclusions:
The oral LD50 is >2000 mg/kg b.w. Not classified