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Diss Factsheets
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EC number: 205-592-6 | CAS number: 143-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A published study containing sufficient details to regard it as reliable for use in hazard assessment. Limited experimental detail provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- The safety of propylene glycol and other humectants
- Author:
- Motoyoshi et al
- Year:
- 1 984
- Bibliographic source:
- Cosmetics and Toiletries 99, 83-91
Materials and methods
- Type of study / information:
- Human skin irritation study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- 48 hr patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethanol
- Details on test material:
- EC Number 203-919-7
EC Name 2-(2-ethoxyethoxy)ethanol
CAS Number 111-90-0
Molecular formula C6H14O3
IUPAC Name 2-(2-ethoxyethoxy)ethanol
Type of substance
Composition mono constituent substance
Origin organic
Trade names DEGEE, diethylene glycol methyl ether
diethylene glycol monoethyl ether (Wako Junyaku). Unknown impurities.
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- 48 hr occlusive patch tests were conducted in 34 health Japanese male adults .
The size of lint used in the patch tests was a 15mm2 and the amount of substance applied was 0.05ml/patch of a 50% (w/w) solution on the upper back. Skin was scored 30 minutes after patch removal. - Exposure assessment:
- not specified
Results and discussion
- Results:
- 45% of those tested showed erythema, edema or vesicles. An additional 20 % had definite erythema and approximately 35% had possible erythema.
No other details were reported.
Applicant's summary and conclusion
- Conclusions:
- The substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.The test substance was a skin irritant under the conditions of this study.
- Executive summary:
The substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.In a 48hr occlusive patch irritation study in Japanese subjects, 0.05ml of 50% (w/w) 2 -(2 -ethoxyethoxy)ethanol induce irritation observed as erythema, edema or vesicles in most subjects. Similar results were seen with other tested substances such as propylene and dipropylene glycol.
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