Registration Dossier
Registration Dossier
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EC number: 608-291-1 | CAS number: 2890-61-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- pre-test with one animal
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-methylcyclohexane-1-carbonyl chloride
- EC Number:
- 608-291-1
- Cas Number:
- 2890-61-1
- Molecular formula:
- C8H13ClO
- IUPAC Name:
- 1-methylcyclohexane-1-carbonyl chloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- other: 24h
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
A macroscopical assessment was not possible.
Microscopical investigations after sacrifice revealed a strongly irritating to corrosive property of the test substance.
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