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EC number: 939-448-5 | CAS number: -
Primary skin irritation/corrosion study with 3-(Isotridecyloxy)-1-propane amine in the rabbit (semi-occlusive application) according to OECD 404.
One rabbit was exposed to three samples of 0.5 mL of 3-(Isotridecyloxy)-1-propane amine applied to separate skin-sites on intact, clipped skin using a semi-occlusive dressing. The exposure periods were 3 minutes, 1 hour and 4 hours, respectively. Skin reactions were assessed at least once daily for 4 days after treatment and 7 and 14 days after exposure. Based on the severity of the skin reactions, no further animals were exposed.
Exposure to 3-(Isotridecyloxy)-1-propane amine resulted in erythema and oedema in the treated skin areas. Up to very slight erythema and oedema was observed on Day 1, progressing into severe erythema and oedema from 24 hours after exposure on all treated skin sites. The skin irritation remained present up the end of the observation period (14 days after exposure) on all treated skin sites. Reduced flexibility of the skin was observed between 24 hours and 7 days after exposure on all treated skin sites. A dry wound was visible at 7 days after exposure on the 3-minute skin site, and at 72 hours and 7 days after exposure on the 1- and 4-hour skin site. A bald, noticeable white skin (indicating full thickness destruction of the skin), and superficial redbrown eschar formation was observed at 14-days after exposure on all treated skin sites.
The bald, noticeable white skin observed at 14-days after exposure on all treated skin sites was indicative of full thickness destruction of the skin, and indicated that corrosion of the skin had occurred by dermal application of 3-(Isotridecyloxy)-1-propane amine to the intact rabbit skin.
Based on these results and according to the:
-Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2007), 3-(Isotridecyloxy)-1-propane amine should be classified as : skin corrosive (Category 1B).
- Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures, 3-(Isotridecyloxy)-1-propane amine should be classified as Corrosive (Category 1B) and labeled as H314: Causes severe skin burns and eye damage.
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