Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Article of limited reporting; in French

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test material

Constituent 1
Reference substance name:
Lauryloxypropylamine
IUPAC Name:
Lauryloxypropylamine
Constituent 2
Reference substance name:
34630-52-9
Cas Number:
34630-52-9
IUPAC Name:
34630-52-9

Results and discussion

Applicant's summary and conclusion

Conclusions:
Etheramine C12 is in rabbits rapidly distributed and quickly excreted mainly via urine with T1/2 of about half an hour. The data also suggest a quick metabolization.
Executive summary:

SUMMARY. - Lauryloxypropylamine dosage in blood and urines is carried out by fluorimetry after HPLC separation, with dodecylamine as internal standard. Standard curve is linear till lauryloxypropylamine injection of 200 ng. Detection limit is of nearly 5 ng/injection. Lauryloxypropylamine pharmacokinetic study was carried out on rabbits with rapid intravenous administration of a 5 mg/kg dose. Different experimental curves obtained after blood and urine sampling and mathematic analysis allow to describe lauryloxypropylamine behaviour through the organism following an open pharmacokinetic model with two distribution compartments. Elimination half-life calculated time is of 29 mn and distribution volume of 13.37 I/kg.