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EC number: 403-960-2 | CAS number: -
The Substance has been evaluated in the bacterial mutagenicity assay of Maron and Ames (1983), using five strains of Salmonella typhimurium (TAI535, TA1537, TA1538, TA98 and-TA100), and also one strain of Escherichia coli (WP2 uvrA pKM101), following protocols complying with OECD Guidelines Nos. 471 and 472 (OECD, 1983a and 1983b).
In two separate experiments, the compound did not induce any significant, reproducible increases in the observed numbers of revertant colonies in strains TA1535 and WP2 uvrA pKM101 in either the presence or absence of S9.
In the first experiment in strain TAl537 a limited, dose-related increase in the observed number of revertant colonies was obtained. This had only lmited reproducibility in the second experiment.
In strains TA1538, TA98 and TA100 (both with and without S9) significant, dose-related increases in the observed numbers of revertant colonies were obtained in each experiment.
In each experiment, the positive controls responded as expected, indicating that the assay was working satisfactorily.
Under the conditions of this assay, the Substance therefore gave an unequivocal positive, ie mutagenic, response in strains TA1538, TA98 and TA100 in both the presence and absence of an auxiliary metabolising system (S9).
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