2-(phenylmethoxy)naphthalene

Toxicity to reproduction

Administrative data

Endpoint:

one-generation reproductive toxicity

Remarks:

based on test type (migrated information)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: reference study data from SNIF file

Data source

Reference

Reference Type:

other: SNIF data provided by ECHA

Title:

Unnamed

Report date:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(phenylmethoxy)naphthalene

EC Number:

405-490-3

EC Name:

2-(phenylmethoxy)naphthalene

Cas Number:

613-62-7

Molecular formula:

C17 H14 O

IUPAC Name:

2-(benzyloxy)naphthalene

Test animals

Species:

rat

Strain:

other: Wistar Hanlbon (SPF)

Sex:

male/female

Administration / exposure

Route of administration:

oral: feed

Doses / concentrations

Doses / concentrations 1

Remarks:

Doses / Concentrations:
males: 0, 43.6, 224.2 and 1137.6 mg/kg bw
Basis:

Doses / concentrations 2

Remarks:

Doses / Concentrations:
females: 0, 71.1, 351.4 and 1669.1 mg/kg bw
Basis:

No. of animals per sex per dose:

25

Control animals:

yes, plain diet

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

Increased food intake in males. In females decreased food intake and weight loss was reported prior and during pregnancy when given 351.4 mg/kg bw (relative) and 1669.1 mg/kg bw (relative and absolute).
No dose dependent change in conception rate and gestation length. A reduction of implantations and embryo losses after implantation were reported.
Litter size from test group 4 (1669.1 mg/kg bw in females) was reduced. Litter size from test group 3 (351.4 mg/kg bw in females ) was also reduced but still within the range of the historical laboratory control data.

Results: F1 generation

Details on results (F1)

A decrease in average weight was reported in litter from groups 4 (1669.1 mg/kg bw in females and 1137.6 mg/kg bw in males) and 3 (351.4 mg/kg bw in females and 224.2 mg/kg bw in males) after 21 days of lactation. No structural abnormalities compared with controls have been reported.

Effect levels (F1)

Dose descriptor:

NOAEL

Generation:

F1

Effect level:

351.4 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: Litter size reduction in high dose group

Overall reproductive toxicity

Reproductive effects observed:

not specified