Registration Dossier
Registration Dossier
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EC number: 700-857-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
As Rhodimet AT 88 is a transported isolated intermediaite manufactured and used under strictelly controlled conditions with a tonnage higher than 1000 tonnesper year, only acute fish, acute Daphnia magna, algae and microroganisms (Activated sludge respiration inhibition testing) toxicity data are required.
Toxicity to fish:
- In an acute aquatic toxicity study performed in accordance with OECD guideline 203 , zebra fish (Brachydanio rerio) were exposed to Rhodimet AT 88 (ALIMET) at concentrations of 0 (blank), 100, 180, 320, 580 or 1000 mg (active ingredient)/L (nominal) for 96 hours under semi-static conditions. LC50 in the test without pH adjustment at 96 hours was calculated to be 385.9 mg/L. LC50 in the test with pH adjustment at 96 hours was calculated to be 240.0 mg/L. The NOEC is 180 mg/L.
Toxicity to aquatic invertebrates:
- In an acute aquatic toxicity study performed in accordance with OECD guideline 202, Daphnia magna were exposed to Rhodimet AT 88 (ALIMET) at concentrations of 0 (blank), 58, 100, 180, 320, 580 or 1000 mg (active ingredient)/L (nominal) for 48 hours under semi-static conditions.
The LC50 and EC50 (48 hour), without pH adjustment, were determined to be 222 (195-261) and 200 (176-232) mg (a.i.)/L, respectively.
The LC50 and EC50 (48 hour), with pH adjustment, were determined to be 293 (242-361) and 287 (237-352) mg (a.i.)/L, respectively.
Toxicity to algae:
In an algal toxicity study performed in accordance with OECD guideline 201, Selenastrum capricornutum was exposed to Rhomimet AT 88 (Alimet) at concentrations of 0 (control), 10, 18, 32, 58, 100 and 180 mg (active ingredient)/L (nominal) for 72 hours under static conditions.
The ErC50 (72 hour), without pH adjustment, was determined to be 89 mg (a.i.)/L.
The ErC50 (72 hour), with pH adjustment, wasdetermined to be 130 mg (a.i.)/L.
The No-Observed-Effect-Concentration (NOEC) after 72 hours was calculated to be 58 mg (a.i.)/L.
Toxicity to microorganisms:
A study was conducted to assess the effect of Rhodimet AT 88 (ALIMET) on micro-organisms according to OECD guideline 209 . The test material was tested at concentrations of 10, 32, 100, 320 and 1000 mg/L(nominal) and the inoculum (microbial source) was activated sludge of a predominantly domestic sewage. Toxicity to micro-organisms was assessed by measuring the respiration rate.
Under the test conditions, the EC50 (3 hour) of ALIMET was considered to be > 1000 mg/L.
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