Registration Dossier
Registration Dossier
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EC number: 270-126-0 | CAS number: 68411-44-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is summarised in a recognized data source of peer reviewed scientific medical literature.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies in detoxication. 69. The metabolism of alkylbenzenes: n-propylbenzene and n-butylbenzene with further observations on ethylbenzene.
- Author:
- EL MASRY AM, SMITH JN, WILLIAMS RT
- Year:
- 1 956
- Bibliographic source:
- Biochem J. 1956 Sep; 64(1): 50-6.
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: study of metabolism of n-propylbenzene and n-butylbenzene in rabbit.
- Principles of method if other than guideline:
- study of metabolism of n-propylbenzene and n-butylbenzene in rabbit.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- n-propylbenzene
- IUPAC Name:
- n-propylbenzene
- Reference substance name:
- n-butylbenzene
- IUPAC Name:
- n-butylbenzene
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Any other information on results incl. tables
Study observed:
n-propylbenzene: metabolites were reported as hippuric acid 15 (13-16) % of dose, glucuronides of ethylphenylcarbinol and benzyl methylcarbinol 47 (39 -56) % of dose. Benzylmethylcarbinol was reported as the main precursor of hippuric acid.
n-butylbenzene: metabolites were reported as phenylpropyl- and methylphenethyl- carbinylglucuronides 51(42 -60) % of dose, and phenaceturic acid (15 -25%). Methyl-2-phenylethylcarbinol was reported as precursor of phenaceturic acid.
Applicant's summary and conclusion
- Conclusions:
- Butylbenzene components are readily metabolised excreted primarily with urine.
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