Registration Dossier
Registration Dossier
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EC number: 232-384-2 | CAS number: 8012-95-1 Liquid hydrocarbons from petroleum.
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Regulatory accepted model for assessment of chemical substances
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Type of assay:
- other: QSAR
Test material
- Reference substance name:
- data for components
- IUPAC Name:
- data for components
- Details on test material:
- Mineral Paraffin Oil is a complex UVCB substance. Data for components.
Constituent 1
Results and discussion
Any other information on results incl. tables
Overview of QSAR/SAR estimations on mutagenicity potential of Mineral Paraffin Oil
Method
|
Results |
Remarks |
Reference |
Pentadecane, C15H32(CAS No. 629-62-9)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Hexadecane, C16H34(CAS No. 544-76-3)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Heptadecane, C17H36(CAS No. 629-78-7)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Octadecane, C18H38(CAS No. 593-45-3)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Nonadecane, C19H40(CAS No. 629-92-5)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Eicosane, C20H42(CAS No. 112-95-8)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Henicosane, C21H44(CAS No. 629-94-7)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Docosane, C22H46(CAS No. 629-97-0)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Tricosane, C23H48(CAS No. 638-67-5)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Tetracosane, C24H50 (CAS No. 646-31-1)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Pentacosane, C25H52 (CAS No. 629-99-2)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Hexacosane, C26H54 (CAS No 630-01-3)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Heptacosane, C27H56 (CAS No. 593-49-7)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Octacosane, C28H58 (CAS No. 630-02-4)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Nonacosane, C29H60 (CAS No. 630-03-5)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Triacontane, C30H62(CAS No. 638-68-6)
|
|||
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
Activity: NON-Mutagen
|
Supportive data |
CAESAR QSAR model for Mutagenicity v.1.0.0.5 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: Negative for genotoxic carcinogenicity. Negative for nongenotoxic carcinogenicity. |
The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)
|
Toxtree, v. 2.5.0 |
QSAR Method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES |
Result: No alerts for micronucleus assay (Class II) |
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
|
Toxtree, v. 2.5.0 |
Predicted |
Mutagenicity result: Mutagenicity Negative |
Peer reviewed data referred in the US EPA developed QSAR model for regulatory assessment of chemical substances
|
US EPA, T.E.S.T. (Toxicity estimation Software Tool), 2010 |
Applicant's summary and conclusion
- Conclusions:
- Screening of Mineral Paraffin Oil hydrocarbon components for mutagenicity/genotoxicity using several available QSAR models provide negative prediction results for this endpoint.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
