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Administrative data

Key value for chemical safety assessment

Additional information

Screening of Mineral Paraffin Oil hydrocarbon components for mutegenicity/genotoxicity using several available QSAR models provide negative prediction results for this endpoint.

 

Epidemiology studies provide some evidence of mutagenic effects in occupationaly exposed to mineral oil mists workers, including increase in the frequency of chromosomal aberrations in the peripheral blood lymphocytes (glass workers) and mutagenic effect of urine in the Ames assay toS. typhimuriumin the presence of exogenous metabolic system (cold-rolling steel plant workers). However, because workplace exposures are of complex nature, involving many other chemicals, possibly including high concentration of PAH in mineral oil products, the clear cause-effect relationship is not possible to establish.

 

In general, mutagenicity/genotoxicity properties reported for Mineral Oils are attributed to PAH content of these products. Thus, highly or severely refined Mineral Oils are not considered as being mutagenic/ genotoxic. The IP346 assay is used by mineral-oil producers to define if a mineral oil is highly or severely refined. The IP346 assay measures the amount of material extractable in dimethyl sulfoxide (DMSO): mineral oils with a DMSO-extractable content < 3% are considered as highly or severely refined.


Endpoint Conclusion:

Justification for classification or non-classification