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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Respiratory response of guinea pigs to oil mists.
Author:
Costa and Amdur
Year:
1979
Bibliographic source:
Am Ind Hyg Assoc J. Vol. 40 (8): 673-679.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Paraffin oils/waxes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Study results:

 

At ≤40 mg/m3: no alterations were observed; No respiratory irritant effects were seen.

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity studies in animals exposed to Mineral Paraffin Oil via inhalation report similar results being concentration-related accumulation of alveolar macrophages with oil droplets in the lung. Exposure to high aerosol concentrations result in inflammatory responces (lipid pneumonia) to the presence of deposited aerosols.