Registration Dossier
Registration Dossier
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EC number: 700-536-1 | CAS number: 25628-08-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- other: comprehensive hazard assessment on potassium perfluorobutane sulfonate; report by the Australian Government
- Rationale for reliability incl. deficiencies:
- other: secondary literature (review)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Exisiting Chemical Hazard Assessment Report - Potassium Perfluorobutane Sulfonate
- Author:
- Australian Government - Department of Health and Ageing NICNAS
- Year:
- 2 005
- Bibliographic source:
- National Industrial Chemicals Notification and Assessment Scheme - Sydney NSW 2001 - Australia
Materials and methods
Test material
- Reference substance name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- EC Number:
- 249-616-3
- EC Name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- Cas Number:
- 29420-49-3
- IUPAC Name:
- potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
A No Observed Effect Level (NOEL) was established as 100 mg/kg bw/day in males in this study based on significant decreases in serum phosphorus and potassium at doses of 300 and 900 mg/kg bw/day when compared to controls. A No Observed Adverse Effect Level (NOAEL) was established as 300 mg/kg bw/day in females and males in this study based on significant increase in kidney and liver weights, respectively, in animals that received 900 mg/kg bw/day compared to controls. The interpretation of gender specific observation of tail flick in male rats in this study is uncertain.
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