Registration Dossier
Registration Dossier
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EC number: 204-658-1 | CAS number: 123-86-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study performed according to guideline
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Shimizu, H. et al.
- Year:
- 1 985
- Bibliographic source:
- Shimizu, H. et al. 1985. Jpn J Ind Health 27: 400-419. cited in: IUCLID (1995) data sheet for n-butyl acetate.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to B Ames et al. (1975) Mutat Res 31:347-364
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- N-butyl acetate
- EC Number:
- 204-658-1
- EC Name:
- N-butyl acetate
- Cas Number:
- 123-86-4
- Molecular formula:
- C6H12O2
- IUPAC Name:
- butyl acetate
- Details on test material:
- n-butyl acetate: purity 99.6%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2 uvrA
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 1 - 5000 ug/plate
Results and discussion
Test results
- Species / strain:
- other: TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
negative
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