Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Sufficient data for evaluation.

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
Eyes of 6 rabbits were applied with 0.1 mL of the undiluted test substance. Effects on conjunctivae, iris, and cornea were scored 24, 48, and 72 hours after application of the test substance.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: the second eye served as control
Amount / concentration applied:
Amount applied: 0.1 mL (undiluted)
Duration of treatment / exposure:
No data
Observation period (in vivo):
Up to 72 hours
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 24 hour reading
Score:
ca. 91.3
Max. score:
110
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 48 hour reading
Score:
ca. 86.3
Max. score:
110
Irritation parameter:
other: cornea score, iris score, conjunctivae score
Basis:
mean
Time point:
other: 72 hour reading
Score:
ca. 82.7
Max. score:
110
Reversibility:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: after 72 hour reading
Score:
ca. 91.3
Max. score:
110
Reversibility:
not reversible
Other effects:
Not reported

Any other information on results incl. tables

Total irritation score: 91.3 / 110

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information