Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Sufficient data for assessment.

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
no further information

Test system

Type of coverage:
other: no data
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
No data
Observation period:
72 hours
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: mean score of each animals
Time point:
other: abraded and intact skin: after 72 hours
Score:
4
Max. score:
4
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal: mean score of each animal
Time point:
other: abraded and intact skin: after 72 hours
Score:
4
Max. score:
4
Reversibility:
no data
Irritation parameter:
overall irritation score
Basis:
other: mean value overall animals
Time point:
other: abraded and intacxt skin: after 72 hours
Score:
ca. 8
Max. score:
8
Reversibility:
no data

Any other information on results incl. tables

Intact and abraded skin: total irritation score: 8.00 / 8.00

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information