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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1938, 1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No study report but sufficient information for assessment.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Studies in detoxication. 1. the influence of (a) dose and (b) o-m- and p-stubstitution on the suphate detoxication of phenol in rabbits
Author:
Williams BT
Year:
1938
Bibliographic source:
Biochem. J. 32, 878-887
Reference Type:
review article or handbook
Title:
EHC (Environmental Health Criteria) No. 168: Cresols
Author:
WHO
Year:
1995
Bibliographic source:
IPCS (International Programme on Chemical Safety) WHO, Geneva

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Application by oral gavage to rabbits. Urine was collected over 6 days and analysed for total and inorganic sulphate (gravimetric method according to Folin et al., 1932).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: approximately 2 kg
- Housing: singly
- Individual metabolism cages: yes
- Diet "mixed diet": 100 g cabbage , 50 g bran
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°F): 50-60

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on exposure:
No details given
Duration and frequency of treatment / exposure:
6 days
Doses / concentrations
Remarks:
Doses / Concentrations:
290 mg/kg bw/day as aequous solution
No. of animals per sex per dose:
No data
Control animals:
no
Details on study design:
Application by oral gavage to rabbits. Urine was collected over 6 days and analysed for total and inorganic sulphate every two days (gravimetric method according to Folin et al., 1932).

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
No data
Details on distribution in tissues:
No data
Details on excretion:
A mean of 22 % of the applied dose was as conjugate with sulphate.

Metabolite characterisation studies

Metabolites identified:
no

Any other information on results incl. tables

22 % of the administered dose is excreted conjugated with sulphate.

Applicant's summary and conclusion