Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OECD Guideline study. No detailed documentations and no purity specified.

Data source

Reference
Reference Type:
publication
Title:
Bioaccumulation of phenols in zebrafish determined by a dynamic flow-through test
Author:
Butte W, Willig A, Zauke GP
Year:
1987
Bibliographic source:
Kaiser KLE, QSAR in Environmetal Toxicology, Vol. 2, 43-53 by Reidel Publishing Company

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 305 E (Bioaccumulation: Flow-through Fish Test)
Deviations:
not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
age: six to eight months
length: 2.9 to 3.5 cm
average fat content: 30 to 50 mg/g

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater

Test conditions

Test temperature:
25°C
pH:
7.6 to 8.0
Dissolved oxygen:
5 to 8 mg/L
Details on estimation of bioconcentration:
The BCF in fish values were calculated from the kinetics of the uptake and depuration phase of the test substance applying a two-compartment model.

Results and discussion

Lipid content
Lipid content:
ca. 30 - ca. 50 other: mg/g
Time point:
other: no data
Bioaccumulation factor
Type:
BCF
Value:
10.7
Basis:
whole body w.w.
Calculation basis:
kinetic

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified