Registration Dossier

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study available for review. Near guideline non-GLP investigation, well described methods and results, acceptable for assessment.

Data source

Reference
Title:
No information
Author:
Mobil (1989) Thirteen-week dermal administration of vacuum|tower overheads to rats. Mobil Environmental and Health|Sciences Laboratory. Princeton, New Jersey, USA. Study No.|62326.

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Condensates (petroleum), vacuum tower
EC Number:
265-049-4
EC Name:
Condensates (petroleum), vacuum tower
Cas Number:
64741-49-7
IUPAC Name:
64741-49-7
Details on test material:
TS-Freetext:
Vacuum tower overhead (vacuum gas oil, lowest boiling), CAS
No. 64741-49-7, substance group 5A.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
dermal
Duration of treatment / exposure:
Exposure period: 13 wk

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Absolute and relative epididymal, prostate, testes, ovary
and uterus weights were indistinguishable between control
and treated rats.

No treatment-related microscopic changes were present in
either sex.

An assessment of epididymal sperm parameters demonstrated no
alteration in weight of cauda epididymis, the number of
sperm per cauda (both total and per g wet wt tissue) or the
percentage of normal sperm.

Testicular spermatid parameters showed no alteration in
testis weight or spermatid numbers (both total and per g
testis).

Applicant's summary and conclusion

Conclusions:
CL-Freetext:
Dermal administration of vacuum tower overheads at 500 mg/kg
bwt/d, 5 d/wk, for 13 weeks was without effect on
reproductive organ weights and histology in male and female
rats, or on sperm/spermatid parameters in males.

Categories Display