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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Description of key information

In rats the oral LD50 was 4100 mg/kg bw.

Key value for chemical safety assessment

Additional information

Oral route

In a study by Cochran et al (1950), 24 adult Dawley rats (both sexes) were used for determination of the acute oral toxicity of some metal salts among which zirconium di(acetate) oxide. The animals received single 50% aqueous zirconium solutions orally by stomach tube and were observed up to 30 days after exposure. Exposed animals showed a progressive depression and decrease in activity until death occurred. The time of death varied from a few hours to a few days following the administration of the compounds. Few deaths however occurred later than five days after administration. No characteristic physiologic or gross pathologic changes were observed. An oral LD50 of 4100 mg/kg bw was determined for zirconium di(acetate) oxide.

Justification for classification or non-classification

Based on the results of the acute oral toxicity study, zirconium di(acetate) oxide does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.