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EC number: 700-618-7
CAS number: 39202-17-0
Key study performed according to GLP and OECD Guideline 203:The acute toxicity of the test item to the freshwater fish fathead minnow (Pimephales promelas) has been investigated. Given the decline in measured test concentrations it was considered justifiable to base the results on the time-weighted mean measured test concentrations. The 72-Hour LC50 based on the time-weighted mean measured test concentrations was >0.17 mg/L. The No Observed Effect Concentration was 0.17 mg/L.
study was performed to assess the acute toxicity of 9-dodecenoic acid,
methyl ester (9DDAME) (CAS No. 39202-17-0) to fathead minnow (Pimephales
promelas). The method followed was designed to be compatible with
the OECD Guidelines for Testing of Chemicals (1992) No 203, "Fish, Acute
Toxicity Test" referenced as Method C.1 of Commission Regulation (EC)
No. 440/2008 and US EPA Draft Ecological Effects Test Guidelines OPPTS
850.1075 "Fish Acute Toxicity Test, Freshwater and Marine".
a preliminary range-finding test, ten fish were exposed to an aqueous
solution of the test item, at a single concentration of 100% v/v
saturated solution (0.17 mg/L based on time-weighted mean measured test
concentrations) at a temperature of 20 ºC to 21°C
under semistatic test conditions. The test period was 96 hours, however
during the last 24 hours of the test no dissolved test item was detected
in the exposure vessels and hence the results have been calculated using
a 72-hour exposure to the test item. The test item solution was prepared
by stirring an excess (50 mg/L) of test item in dechlorinated tap water
using a propeller stirrer at approximately 1500 rpm for 24 hours. After
the stirring period any undissolved test item was removed by filtration
(0.2 μm Gelman AcroCap filter, first approximate 500 mL discarded in
order to pre-condition the filter) to produce a 100% v/v saturated
solution of the test item. The number of mortalities and any sub-lethal
effects of exposure in each test and control vessel were determined 3
and 6 hours after the start of exposure and then daily throughout the
test until termination after 96 hours.
study showed no toxic effects at saturation.
of the freshly prepared test preparation at 0, 24, and 48 hours showed
measured concentrations to range from 0.836 to 0.933 mg/L. Analysis of
the corresponding old media at 24, 48 and 72 hours showed measured
concentrations of less than the limit of quantitation (LOQ) of the
analytical method (assessed as 0.011 mg/L).
of the freshly prepared test media at 72 hours and the corresponding old
test media at 96 hours showed no detectable test item. It was therefore
considered that the test organisms had not been exposed to the test item
over the final 24 hours of the test period and therefore all results
have been based on a 72-Hour exposure period.
the decline in measured test concentrations over each 24-Hour period, it
was considered justifiable to base the results on the time-weighted mean
measured test concentrations. The time-weighted mean measured
concentration was calculated to be 0.17 mg/L.
on the time-weighted mean measured test concentrations was greater than
0.17 mg/L. The No Observed Effect Concentration was 0.17 mg/L.
that the test item showed no toxic effects over a 72-Hour period at a
time-weighted mean measured test concentration of 0.17 mg/L, and given
the consistency of the measured test item concentrations over the first
72 hours of the exposure period, it is considered likely that the
also be greater than 0.17 mg/L.
in test item within relatively brief periods means that a stable
concentration was not attained. Therefore the test should not be
regarded reliable without restriction. The repeated observation of
virtually complete disappearance suggests that this reflects an inherent
property of the test item, although the cause of this is currently
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