Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The test substance is a white powder with a molecular weight of 659 g/mol. The log P o/w value is 4.2 and the solubility in water is < 0.007 mg/l (20°C). The particle size was examined to be < 18.31μm = 50 % and < 5.98 μm = 10% .

In an acute oral toxicity study, TIF: RAIf (SPF) rats were administered doses of up to 2000 mg/kg body weight per gavage (CIBA-Geigy study, 1992). No mortalities occurred and the LD50 oral was set to be > 2000 mg/kg body weight. However, according to the physico-chemical properties (molecular weight, log P o/w) the test substance is expected to be absorbed through the gastrointestinal tract (ECHA R7c). . Based on the lipophilic properties of the test substance, the liver appears to be the main site of metabolism. The metabolites are assumed to be excreted predominantly via the renal pathway.

The dermal uptake of the test substance is unlikely due to its physico-chemical properties. The penetration rate is assumed to be extremely low and the extent is extremely limited through rat and human split thickness skin membranes. Furthermore, the test substance did not exhibit any acute dermal toxicity, skin irritative / corrosive , eye irritative or skin sensitisation properties , respectively.