Registration Dossier
Registration Dossier
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EC number: 204-552-5 | CAS number: 122-52-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (adopted 1981)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethylphosphite
- IUPAC Name:
- Triethylphosphite
- Details on test material:
- Purity: no data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: HC:NZW rabbits
- Details on test animals or test system and environmental conditions:
- Sex: female
Mean weight: 3.5 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Concentration: 100% - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 10 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
0.5 mL undiluted test substance was applied on a gauze pad (2.5 x 2.5 cm) under semi-occlusive conditions to the intact skin.
REMOVAL OF TEST SUBSTANCE
- Washing: After the end of the exposure time the application sites were washed with water.
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Skin effects were scored according to the Draize system at 1, 24, 48, 72 hours and at 7 and 10 days after the end of the exposure.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No edema were observed throughout the whole study period.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- < 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: No raw data available. Description of results led to the conclusion that the mean values for erythema have been smaller than 2.
- Irritant / corrosive response data:
- All six animals showed slight or clearly visible erythema (grade 1 or 2) up to 48 hours. At day 7, slight erythema (grade 1) still persisted in 5 animals, but had resolved in all but one animal at day 10. None of the animals showed edema at any of the observations.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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