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EC number: 700-855-6
CAS number: -
Sprague-Dawley rats were dosed by gavage with 0, 250, 500 and 1000 mg/kg bw/day
C12/16 APG for 90 days. An additional 5 male and 5 female control and
high dose rats were used as a recovery group. There were two fatalities,
neither of which was linked to the test material. No treatment-related
changes in body weights, organ weights, or biochemistry or hematology
parameters were observed. Absolute gonad weights were decreased in all
test groups, but the decrease was not considered treatment related by
the researchers because of a lack of a dose-response. A dose-dependent,
slowly reversible, irritation and ulceration of the forestomach mucosa
was observed in animals of the 0.5 and 1 g/kg bw groups. Systemic
toxicity was not observed in any group. The NOAEL for systemic toxicity
was 1000 mg/kg bw. The NOEC for “local compatibility” (irritation and
ulceration of the mucous membrane of the forestomach) was deduced as
2.5% active ingredient.
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