Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-829-7 | CAS number: 922165-31-9
Endpoint summary
Administrative data
Description of key information
The skin irritation/corrosion study was performed according to OECD Guideline 404 and GLP principles.
Three eye irritation studies were conducted with the substance.
The in vivo eye irritation/corrosion study was performed equivalent or similar to OECD Guideline 405 and GLP principles, but tested with a 50% dilution of the substance. An in vitro eye irritation/corrosion study (BCOP) was performed according to OECD Guideline 437 and GLP principles. And an in vitro eye irritation/corrosion study (EpiOcular)was performed according to GLP principles.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In the in vivo skin irritation test, the test substance is considered to be not irritating to rabbit skin.
In the in vivo eye irritation test, 50% substance was not irritating to eyes of rabbits. No conclusions can be drawn on 100% test substance.
In the in vitro eye irritation test (BCOP), the 100% substance was not severe irritant or corrosive in the Bovine Corneal Opacity and Permeability test. Also in the in vitro eye irritation test (EpiOcular), the 100% substance showed no irritation.
Justification for classification or non-classification
Based on the absence of skin irritation in a reliable in vivo study, the substance needs not to be classified and labelled for skin irritation according to CLP.
Based on the available information on eye irritation, two negative in vitro eye studies tested with 100% substance and a negative in vivo study tested with 50% substance, no conclusions can be drawn as negative in vitro data are not accepted for definite conclusion on classification and labelling. As in vivo data are only available for a 50% dilution of the substance, no conclusions can be drawn on 100% substance. As a result, the classification and labelling according to CLP for eye irritation is therefore inconclusive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
