Registration Dossier
Registration Dossier
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EC number: 205-642-7 | CAS number: 144-83-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Test material form:
- not specified
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Details on exposure:
- 500 mg/kg
- Duration of treatment / exposure:
- 6, 24 and 48h
- Frequency of treatment:
- No data
- Post exposure period:
- 6, 24 and 48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mg/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Positive control(s):
- No data
Examinations
- Details of tissue and slide preparation:
- bone marrow
- Evaluation criteria:
- No data
- Statistics:
- No data
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The test substance did not cause chromosome Aberrations in in vivo in rat bone marrow cells under the experimental condition. - Executive summary:
The study were performed to assess the chromosome aberration of the test substance to rat bone marrow cells.500 mg/kg was applied orally to male and female rats. The rats were killed after 6, 24 and 48 hours later. No chromosome damaging was found. Thus, we can conclude the test substance dose not cause chromosome Aberrations in in vivo in rat bone marrow cells.
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