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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to OECD 105 and EEC method A6 and in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,3,3-tetrafluorooxetane
EC Number:
700-202-5
Cas Number:
765-63-9
Molecular formula:
C3H2F4O
IUPAC Name:
2,2,3,3-tetrafluorooxetane
Details on test material:
- Name: TFO
- Chemical name: 2,2,3,3-Tetrafluorooxetane
- Appearance: Transparent liquid
- Storage conditions: Room temperature
- Lot number: TFOS285001
- Purity: 99%
- Expiry date: 30 April 2010
- Date received: 16 October 2008

Results and discussion

Water solubility
Water solubility:
24 g/L
Temp.:
20 °C
pH:
0.1 - 0.6
Details on results:
The detector calibration was found to be linear over the range 0 to 1600 mg/l of standard solutions in acetone with a regression coefficient of 0.9991.
The water solubility of TFO was 23.9 ± 1.9 g/l. The low pH of the samples was considered to be due to the presence of acidic degradates. Table 3 presents the primary data for this test.
There were no interfering peaks in blank control solutions, whilst a mean recovery of approximately 90% of TFO from fortified control samples was achieved and deemed to be acceptable.

Any other information on results incl. tables

The very low pH of the test solutions at the end of the test period (pH 0.1 to 0.6) suggests that the substance was hydrolysed during testing. This is consistent with the observation in the biodegradation test that "The test item was hydrolyzed completely and converted into 2,2-difluoro-3-hydroxy-propionic acid and fluoride ion under the test condition of the study". This also explains why the log Pow is so high (log Pow = 5.3) for an apparently water soluble substance.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
TFO was found to have a water solubility of 24 g/l at 20°C.