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EC number: 206-340-8 | CAS number: 328-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(trifluoromethyl)benzoyl fluoride
- EC Number:
- 206-715-6
- EC Name:
- 4-(trifluoromethyl)benzoyl fluoride
- Cas Number:
- 368-94-5
- Molecular formula:
- C8H4F4O
- IUPAC Name:
- 4-(trifluoromethyl)benzoyl fluoride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- First dose 2000 mg/kg
A second dose of 200 mg/kg to an additional group of 5 male and 5 female
A third dose fo 1000 mg/kg to an additional group of 5 male and 5 female - No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 178 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg dose : 0% of mortality in males and females
1000 mg/kg dose : 0% of mortality in males; 20% of mortality in females
2000 mg/kg dose : 100% of mortality in males and females - Clinical signs:
- Sedation, convulsions, hunched posture, ventral recumbency, uncoordinated movements, dyspnea, diarrhea and /or ruffled fur were obseved in the animals of dose group 2000 mg/kg.
Sedation, hunched posture, dyspnea, emaciation, lids half closed and/or ruffled fur were observed in the animals of dose group 100 mg/kg. No clinical signs were observed in the animals of dose group 200 mg/kg. - Body weight:
- within the range
- Gross pathology:
- white discolored lungs was observed in one female of dose group 2000 ng/kg. No macroscopic findings in the other animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose for the acute oral toxicity in rats of both sexes observed for a period of 14 days is: LD50 1178 mg/kg.
for males 1174 mg/kg
for females 1031 mg/kg
with 90% CI of:
males/females 771-2324 mg/kg
males 601-5085 mg/kg
females 561-2843 mg/kg
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