3-(trifluoromethyl)benzoyl fluoride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1997

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-(trifluoromethyl)benzoyl fluoride

EC Number:

206-715-6

EC Name:

4-(trifluoromethyl)benzoyl fluoride

Cas Number:

368-94-5

Molecular formula:

C8H4F4O

IUPAC Name:

4-(trifluoromethyl)benzoyl fluoride

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

First dose 2000 mg/kg
A second dose of 200 mg/kg to an additional group of 5 male and 5 female
A third dose fo 1000 mg/kg to an additional group of 5 male and 5 female

No. of animals per sex per dose:

5

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 178 mg/kg bw

Based on:

test mat.

Mortality:

200 mg/kg dose : 0% of mortality in males and females
1000 mg/kg dose : 0% of mortality in males; 20% of mortality in females
2000 mg/kg dose : 100% of mortality in males and females

Clinical signs:

Sedation, convulsions, hunched posture, ventral recumbency, uncoordinated movements, dyspnea, diarrhea and /or ruffled fur were obseved in the animals of dose group 2000 mg/kg.
Sedation, hunched posture, dyspnea, emaciation, lids half closed and/or ruffled fur were observed in the animals of dose group 100 mg/kg. No clinical signs were observed in the animals of dose group 200 mg/kg.

Body weight:

within the range

Gross pathology:

white discolored lungs was observed in one female of dose group 2000 ng/kg. No macroscopic findings in the other animals.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The median lethal dose for the acute oral toxicity in rats of both sexes observed for a period of 14 days is: LD50 1178 mg/kg.

for males 1174 mg/kg
for females 1031 mg/kg

with 90% CI of:
males/females 771-2324 mg/kg
males 601-5085 mg/kg
females 561-2843 mg/kg