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EC number: 700-823-1 | CAS number: 55514-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- But audited by Quality Assurance
Test material
- Reference substance name:
- 3-[4-(5,6-diphenyl-1,2,4-triazin-3-yl)phenyl]-5,6-diphenyl-1,2,4-triazine
- EC Number:
- 700-823-1
- Cas Number:
- 55514-22-2
- Molecular formula:
- C36H24N6
- IUPAC Name:
- 3-[4-(5,6-diphenyl-1,2,4-triazin-3-yl)phenyl]-5,6-diphenyl-1,2,4-triazine
- Details on test material:
- - Name of test material (as cited in study report): CH022 WP30
- Physical state: powder
- Analytical purity: 99.8 %
- Purity test date: January 7th, 2012
- Lot/batch No.: LP140
- Stability under test conditions: stable
- Storage condition of test material: at room temperature in a dark and well ventilated place
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Janvier, Le Genest-Saint-Isle, France
- Weight at study initiation: males: approximately 250 g, females: approximately 200 g
- Housing: 1 animal per cage
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-2
- Humidity (%): between 40 and 70
- Air changes (per hr): > 10 full air changes
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): direct application of 2000 mg/kg bw - Duration of treatment / exposure:
- 24 +/- 1 hours
- Observation period:
- 14 days
- Number of animals:
- 5 males and 5 females
- Details on study design:
- TEST SITE
- Area of exposure: 6 x 5 cm
- % coverage: 10 %
- Type of wrap if used: Gauze patch held in close contact with the skin by means of a non occlusive tape Micropore
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the testsite was wiped with a cotton pad soaked with purified water
- Time after start of exposure: 24 +/- 1 hours
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- 0
- Basis:
- mean
- Time point:
- other: 15 days
- Score:
- 0
- Irritant / corrosive response data:
- None
- Other effects:
- Desquamation on D5 in one female and on D8 in 2 females
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Neither erythema nr edema was observed in any animal tested so the individual irritation index was 0 for all animals. Consequently the Primary Irritation Index of the group was also 0.
- Executive summary:
The objective of this study was to evaluate the potential toxicity of the test item CH0222 WP30 after a single topical application for a 24-hour exposure period on Wistar rat skin.
5 male and 5 female Wistar rats (RjHan: WI, SPF albino rats from Janvier) were treated at 2000 mg/kg corresponding to the limit test.
On the day of application (Dl), a weight based quantity of test item was moistened with purified water and applied directly onto the dorsal part of the trunk of each animal which had been clipped the day before. The test item was evenly spread over the application site which represented at least lO% of the body surface. The application site was then covered with a gauze patch held in close contact with the skin by means of a non occlusive tape for a 24h exposure period. At the end of the exposure period, the patch was removed and the test site was wiped with a cotton pad soaked with purified water.
Animals were observed at least once daily for mortality and general clinical signs for 15 days and were weighed on Dl, D3, D8 and D15.
Skin reactions were evaluated for all animals approximately 1 hour (D2), 24h (D3), 48h (D4) and 72h (DS) after patch removal at the end of the contact period and on D8 and Dll. The responses, erythema and edema, were scored according to a table graded from 0 (no skin reaction) up to 4 (severe reaction).
Neither erythema nor edema was observed so that the Individual Irritation Index was equal to o for all animals. Consequently, the Primary Irritation Index of the group was also equal to O. Desquamation was present on DS in one female and on D8 in 2 females.
CH0222 WP30 was non irritating to skin.
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