Registration Dossier

Administrative data

Endpoint:
eye irritation
Remarks:
other: not provided in study summary
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1988
Report Date:
1988

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 84/449/EWG, B.5 OECD 405 (1981)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Nature of substance: unverdunnt

Test animals / tissue source

Species:
rabbit
Strain:
other: Weiber Neuseelander

Test system

Amount / concentration applied:
0.1ml
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
mean
Time point:
other: not included in study summary
Score:
1.7
Max. score:
3
Remarks on result:
other: Max. duration: h; Max. value at end of observation period
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: not included in study summary
Score:
1.45
Max. score:
3
Remarks on result:
other: Max. duration: h; Max. value at end of observation period
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: not included in study summary
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period 0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: not included in study summary
Score:
0.28
Max. score:
1
Remarks on result:
other: Max. duration:72 h; Max. value at end of observation period

Applicant's summary and conclusion

Interpretation of results:
other: not classified