Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Studies on the design of animal tests for the corrosiveness of industrial chemicals
Author:
Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P, Schöbel C, Suberg H, Zechel HJ
Year:
1985
Bibliographic source:
Fd. Chem. Toxic. 23(6): 615-617

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
Molecular formula:
Cl4Ti
IUPAC Name:
titanium(4+) tetrachloride

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: various breeders, not specified
- Weight at study initiation: 2-4 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
standardized laboratory conditions, no further data

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 in ml or g
Duration of treatment / exposure:
1 and 4 hours
Observation period:
7 days
Number of animals:
6 for each exposure time
Details on study design:
TEST SITE
- Area of exposure: dorsal and lateral parts of the trunk
- % coverage: unspecified, gauze pads with 3x3 cm were used
- Type of wrap if used: air permeable circular bandage


REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with water and dried
- Time after start of exposure: either after 1 or 4 hours


SCORING SYSTEM: as described in the OECD guideline 404

Results and discussion

In vivo

Results
Irritation parameter:
other: full thickness destruction
Basis:
mean
Time point:
other: 1 h
Score:
> 4
Max. score:
4
Reversibility:
not reversible

Any other information on results incl. tables

The publication indicates that semi-occlusive exposure of the shaved rabbit skin to titanium tetrachlorid for 1 and 4 hours leads to a labbeling with R34 as titanium tetrachlorid is corrosive according to EU-criteria. This means that full thickness destruction of the skin occured after exposure for 1 hour. The test substance therefore has to be classified in Cat. 1B (skin irritation/corrosion) according to GHS-criteria.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information