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EC number: 700-485-5 | CAS number: 939402-02-5
§ OECD Guidelines for the Testing of Chemicals No. 402 “Acute Dermal Toxicity” (adopted 24 February 1987)
§ Method B3 Acute Toxicity (Dermal) of Commission Regulation (EC) No. 440/2008
Initially, two animals (one male and one female) were given a single, 24-hour, semi-occluded dermal application of the undiluted test material to intact skin at a dose level of 2000 mg/kg bodyweight. Based on the results of the initial test, a further group of eight animals (four males and four females) was similarly treated. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
Mortality: There were no deaths.
Clinical Observations: Increased respiratory rate and/or hunched posture were noted in two animals. No other signs of systemic toxicity were noted.
Dermal Irritation: There were no signs of dermal irritation.
Bodyweight: All animals showed expected gains in bodyweight over the study period.
Necropsy: No abnormalities were noted at necropsy.
The acute dermal median lethal dose (LD50) of the test material in the Wistar strain rat was found to be greater than 2000 mg/kg. bodyweight.
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