Registration Dossier
Registration Dossier
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EC number: 211-656-4 | CAS number: 681-84-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
- Data for the structurally analogous substance tetraethyl orthosilicate (CAS 78-10-4), which shares the same hydrolysis product as the registered substance, indicate that short-term toxicity to fish is low. Tetraethyl orthosilicate hydrolyses rapidly (half-life 4.4 h) to silicic acid and ethanol (CAS 64-17-5). The registered substance, tetramethyl orthosilicate, also hydrolyses rapidly (half-life <3 min at pH 4, 7 and 9 at approximately 20°C) but in this case to silicic acid and methanol (CAS 67-56-1).
- The risk characterisation ratios (RCRs) based on PNECaqua(freshwater)derived from existing data for methanol are <1.
Testing for long-term toxicity to fish is not considered necessary because:
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