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EC number: 251-156-3 | CAS number: 32687-78-8
The 21-d NOEC is ≥10 mg/L in aquatic invertebrates (Daphnia magna).
According to regulation (EC) No 1907/2006, Annex XI, paragraph 1.5., substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or "category" of substances. Environmental effects or environmental fate may be predicted from data for reference substance(s) within the group by interpolation to other substances in the group (read-across approach).
In a 21-day chronic toxicity study on a structural analogue (EC No 255 -392 -8), Daphnia magna were exposed to Thiodiethylene bis[3- (3,5-di-tert-butyl-4-hydroxyphenyl)propionate] at nominal (loading) concentrations of 0 (control) and 10 mg/L under semi-static, daily renewal conditions in accordance with the OECD 211 guideline.
The water pH, temperature and dissolved oxygen were within acceptable guideline specifications. Mortality, reproduction and sublethal effects were observed daily. The following overall effect concentrations (mg/L) are for the most sensitive endpoint (reproduction) and were obtained based on nominal (loading) concentrations: LOEC > 10 mg/L NOEC ≥ 10 mg/L. No significant mortality or any other additional significant adverse effects or abnormal behavior were observed in any of the test treatments. The data were not sufficient to calculate ECx values for reproduction or mortality.
Concentration control analysis was not performed since the analytical detection limit was above the water solubility of the test substance. However, all reasonable efforts were taken to produce a saturated solution of the test substance in test media, following the guidance in OECD 23. According to OECD 23, for tests with chemicals that cannot be quantified by analytical methods at the concentrations causing effects, the effect concentration can be expressed based on the nominal concentrations. The results in this study are consistent with all validity criteria and the test is valid according to the guidelines of this study. No deviations from test guidelines or other incidents occurred during the course of the reported test which may have influenced the results.
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