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Additional information

The mutagenicity of Campholen aldehyde was studied with the mutant strain TA100 of Salmonella typhimurium using the standard plate incorporation assay with and without liver homogenates (S9) as the metabolic activation system. Campholen aldehyde was tested in concentrations of 15 to 5000 µg per plate in the presence and absence of S9. In the absence and presence of S9-mix, Campholen aldehyde was slightly bacteriotoxic towards the strain TA100 at 1500 µg/plate and at 5000 µg/plate background lawn was nearly absent and no revertants were found. In the concentration range investigated, Campholen aldehyde did not induce any increase in the mutation frequency of the tester strain TA100 in the presence and absence of a metabolic activation system. These results indicate that Campholen aldehyde, under the experimental conditions described, was not mutagenic to Salmonella typhimurium strain TA100 in the presence and absence of a metabolising system.

Justification for selection of genetic toxicity endpoint
Substance is an intermediate and only available data need to be submitted. Only one study on the genotoxicity of the substance is available.

Short description of key information:
(R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde was non-mutagenic in Salmonella typhimurium strain TA100 according to a study performed in line with OECD Guideline 471 and EU Method B13/14.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification