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EC number: 224-815-8 | CAS number: 4501-58-0
Irritation screening tests
Undiluted test substance produced grades of 1 with scabbing and blanching. The 50% w/v concentration in Spectrum Mineral Oil Light produced grades of 1 with blanching. The remaining test concentrations in the same vehicle produced grades of 1 and ±; additionally the 25% w/v concentration produced blanching and the 10% concentration produced scabbing on one site. The test concentrations in Squibb Mineral Oil all produced grades of 1 and ±.
A 50% w/v concentration in Squibb Mineral Oil was chosen for use as induction for the test group; this level was chosen as the highest concentration causing no greater than mild to moderate primary irritation. Undiluted Squibb Mineral Oil was utilised as the vehicle control.
A 25% w/v concentration in Squibb Mineral Oil was chosen for use at primary challenge for the test group and vehicle control; this level was chosen as the highest concentration causing no more than slight primary irritation.
A 20% w/v concentration in Squibb Mineral Oil was chosen for use as rechallenge for the test group and naive control group; this level was chosen in an effort to reduce the irritation noted in controls.
Incidence and severity of responses
Table 1: Incidence and severity results
TMID: Campholenic aldehyde
VMID: Squibb Mineral Oil
The potential of Campholenic Aldehyde, as a 50% w/v formulation in Squibb Mineral Oil, to produce delayed contact hypersensitivity in guinea pigs was evaluated using an adaptation of the method of Rtiz and Buehler*.
Following primary challenge using Campholenic Aldehyde, as a 25% w/v formulation in Squibb Mineral Oil, the incidence of grade 2 responses in the test group (2 of 20) was compared to that of the vehicle control group (0 of 10). The incidence and severity of these responses in the test group were slightly greater than those produced by the vehicle control group indicating that the sensitisation had been induced. A rechallenge was conducted to evaluate the responses at a lower concentration in an effort to reduce the irritation level in the control group.
Following rechallenge using Campholenic Aldehyde, as a 20% w/v formulation in Squibb Mineral Oil, the incidence of the grade 2 responses in the test group (2 of 20) was compared to that of the naive control group (0 of 10). The incidence and severity of these responses in the test group were again greater than those produced by the naive control group confirming that sensitisation had been induced.
In conclusion, under the conditions of this test Campholenic Aldehyde was found to be a sensitiser.
*Ritz and Buehler, Current Concepts in Cutaneous Toxicity, ed. Drill and Lazar (Academic Press, 1980) pp. 25-40.
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