Registration Dossier

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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

For short and long term toxicity to fish, there is no data available for this substance. However, key, weight-of-evidence and supporting data is available for structural analogues. The data is read across to this substance based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.

Measured or estimated data for short-term toxicity to aquatic invertebrates; long-term toxicity to aquatic invertebrates; toxicity to algae and cyanobacteria; and toxicity to microorganisms are available for the registered substance.

The substances are poorly soluble and made of constituents with various water solubility. As a consequence, the exposures were performed with Water Accommodated Fractions (WAFs). Therefore, the results are based on nominal loadings. The toxicity level was never reached in any fish study despite the high loading level tested. Therefore, this substance is considered to display no acute aquatic toxicity based on an analogue read across approach.

For the chronic effects, very long term exposure to 1% pristane, 1% dodecylcyclohexane or 1% n-alkanes in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible. Long-term -toxicity to aquatic invertebrates was predicted by a PETROTOX computer model. An estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value of >1000 mg/l based on reproduction of Daphnia magna was determined.

Additional information

For short and long-term toxicity to fish, there is no data available for this substance. However, key, weight-of-evidence and supporting data is available for structural analogues.

Short-term toxicity to fish

Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 96-h LL50 (mortality) for juveniles of the marine fish Scophthalmus maximus of > 1028 mg/L (based on nominal loading rate).

The toxicity level was never reached in any study despite the high loading level tested. Therefore, this substance is considered to display no acute toxicity to fish based on an analogue read across approach.

Long-term toxicity to fish

1% pristane, 1% dodecylcyclohexane or 1% n-alkanes long-term exposures in fish diet reduced fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects were reversible.No NOELR or NOEC value has been determined for long-term toxicity to fish.

Measured or estimated data for invertebrates and algae are available for the registered substance.

Short-term toxicity to invertebrates

48-hour LL50> 100 mg/l based on WAF loading rate. This substance is considered to display no acute toxicity to aquatic invertebrates

Long-term toxicity to invertebrates

21-day NOELR >1000 mg/l based on reproduction (estimated by Petrotox computer model (PETROTOX-UDM_ver3.01-2006-01438-01-E)).

 

Toxicity to algae and cyanobacteria

72-hour EL50>100 mg/l and NOELR ≥100 mg/l for effects on growth rate based on WAF loading rate. This substance is considered to display no acute toxicity to algae.

 

Toxicity to microorganisms

The Hydrocarbons, C14-C16, n-alkanes, isoalkanes, <2% aromatics, estimated protozoan 48-hr EL50 value is >1000 mg/L based on growth inhibition of Tetrahymena elliotti. The value was estimated using the Petrotox computer model (PETROTOX-UDM_ver3.01-2006-01438-01-E). This substance is considered to display no toxicity to aquatic microorganisms